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Integrin signalling adaptors: not only figurants in the cancer story Nature Reviews Cancer 10, 858 (2010). doi:10.1038/nrc2967 Authors: Sara Cabodi, Maria del Pilar Camacho-Leal, Paola Di Stefano & Paola Defilippi Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling platforms that drive cellular transformation upon integrin-dependent adhesion and growth factor receptor activation. The understanding of the biological effects that are regulated by these adaptors in tumours might be crucial for the
Contribution of positron emission tomography in pleural disease. Rev Mal Respir. 2010 Oct;27(8):e47-53 Authors: Duysinx B, Corhay JL, Larock MP, Withofs N, Bury T, Hustinx R, Louis R INTRODUCTION: Positron emission tomography (PET) now plays a clear role in oncology, especially in chest tumours. We discuss the value of metabolic imaging in characterising pleural pathology in the light of our own experience and review the literature. BACKGROUND: PET is particularly useful in characterising malignant pleural pathologies and is a factor of prognosis in mesothelioma. Metabolic imaging also provides clinical information for staging lung cancer, in researching the primary tumour in metastatic pleurisy and in monitoring chronic or recurrent pleural pathologies. CONCLUSIONS: PET should therefore be considered as a useful tool in the diagnosis of liquid or solid pleural pathologies. PMID: 20965393 [PubMed - in process] www.ncbi.nlm.nih.gov...Read On
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