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    Despite this finding, the overall benefits of selenium in this study still appeared to outweigh the risks by a significant amount. As pointed out in an earlier report (Journal of the American Medical Association 1996;276:1957–63), the total number of cancer deaths was 50% lower in the selenium group than in the placebo group. In addition, the total number of cancers (excluding skin cancers) was reduced by 37%; the incidence of lung cancer was reduced by 46%, colorectal cancer by 58%, and prostate cancer by 63%.
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    COLUMBIA, Mo. (AP) — The Missouri State Fair often is synonymous with hot summer days. Read more on NewsOK.com
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    As far as cancer treatments go, Bernie Schmidt has seen it all. He's had soft-tissue sarcoma cancer, colorectal cancer, skin cancer and "you won't believe it," he added-breast cancer.
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    (Best Syndication News) - Spanish researchers found that compounds in grapes can help protect the skin from the sun’s ultraviolet rays. Polyphenolic substances that come from the flavonoids found in grapes can reduce the UVA and UVB rays ability to cause damaging 'reactive oxygen species' (ROS) from developing. The study was published in the Journal of Agricultural and Food Chemistry. Marta Cascante, a biochemist at the University of Barcelona (Spain) and director of the research project, said that the grape extracted compounds activated the JNK and p38 enzymes, which offered the sun protection. Ultraviolet rays are shown to contribute to skin cancer, sunburn, and premature aging. Polyphenolic extracts could be used to make new UV sunscreen protection skin products. read more
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    Nonmelanoma skin cancer is the most common cancer in the United States, where DNA-damaging ultraviolet B (UVB) radiation from the sun remains the major environmental risk factor. However, the critical genetic targets of UVB radiation are undefined. Here we show that attenuating PTEN in epidermal keratinocytes is a predisposing factor for UVB-induced skin carcinogenesis in mice. In skin papilloma and squamous cell carcinoma (SCC), levels of PTEN were reduced compared with skin lacking these lesions. Likewise, there was a reduction in PTEN levels in human premalignant actinic keratosis and malignant SCCs, supporting a key role for PTEN in human skin cancer formation and progression. PTEN downregulation impaired the capacity of global genomic nucleotide excision repair (GG-NER), a critical mechanism for removing UVB-induced mutagenic DNA lesions. In contrast to the response to ionizing radiation, PTEN downregulation prolonged UVB-induced growth arrest and increased the activation of the Chk1 DNA damage pathway in an AKT-independent manner, likely due to reduced DNA repair. PTEN loss also suppressed expression of the key GG-NER protein xeroderma pigmentosum C (XPC) through the AKT/p38 signaling axis. Reconstitution of XPC levels in PTEN-inhibited cells restored GG-NER capacity. Taken together, our findings define PTEN as an essential genomic gatekeeper in the skin through its ability to positively regulate XPC-dependent GG-NER following DNA damage. Cancer Res; 71(15); 5287–95. ©2011 AACR.
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