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    In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. In this study, we investigated the contribution of plasmacytoid dendritic cells (pDC) in the establishment of immune tolerance in a cohort of 44 ovarian cancer patients. In the tumor and malignant ascites, CD4+CD123+BDCA2+ pDC were the most abundant dendritic cell subset; however, they were profoundly depleted in peripheral blood. The presence of pDC in primary ovarian cancer, but not ascites, was an independent prognostic factor associated with early relapse. Following chemotherapy, we observed a partial restoration of blood pDC levels in patients in complete remission. These findings show preferential recruitment of pDC into tumors where they express a partially mature phenotype that may reflect an in situ activation. Importantly, compared with pDC found in ascites or blood, tumor-associated pDC (TApDC) produced less IFN-?, TNF-?, IL-6, macrophage inflammatory protein-1?, and RANTES in response to toll-like receptor stimulation, and alterations in pDC functions were mainly mediated through tumor-derived TNF-? and TGF-?. Unlike ascites-derived pDC, TApDC induced IL-10 production from allogeneic naive CD4+ T lymphocytes, suggesting the existence of a paracrine immunosuppressive loop. Taken together, our findings indicate that both local and systemic dysfunction of pDC play a critical role in the progression of ovarian cancer via induction of immune tolerance. Cancer Res; 71(16); 5423–34. ©2011 AACR. cancerres.aacrjournals.org


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    Below, we have discussed some tips that might help you in preventing ovarian cancer: Taking contraceptive pills can help women in preventing the onset of ovarian cancer. According to statistics obtained from a medical study, the risk of ovarian cancer is 50% less in women taking hormonal contraceptive pills compared to the women who don’t use any such pills for birth control. According to experts, the longer  the duration of using these pills, the less will be your chances of getting ovarian cancer. However, women having BRCA gene mutation might experience an increase in their risk of getting breast cancer after using contraceptive pills for a prolonged period of time. Eating the right foods and working out regularly are also known to reduce the risk of getting ovarian cancer. To prevent the onset of ovarian cancer women must increase their intake of fibers and reduce the amount of animal fats and alcohol they consume every day. Exercising according to the guidance of a physical trainer helps in maintaining a healthy BMI; studies have revealed that women, who exercises 3 times every week are at lower risk of getting ovarian cancer compared to those who don’t perform any exercise or physical activity at all. It has been seen that women undergoing tubal ligation for preventing pregnancy are at reduced risk of getting ovarian cancer. The exact reason behind this fact is however, yet to be discovered by the scientists. Women, who have ovarian cancer patients in their family, must get themselves diagnosed at regular intervals to make sure that they don’t have possibilities of developing the disease. This will also allow early diagnosis of ovarian cancer, which increases the possibilities of achieving complete cure from the disease.www.justcancer.org


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    In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. In this study, we investigated the contribution of plasmacytoid dendritic cells (pDC) in the establishment of immune tolerance in a cohort of 44 ovarian cancer patients. In the tumor and malignant ascites, CD4+CD123+BDCA2+ pDC were the most abundant dendritic cell subset; however, they were profoundly depleted in peripheral blood. The presence of pDC in primary ovarian cancer, but not ascites, was an independent prognostic factor associated with early relapse. Following chemotherapy, we observed a partial restoration of blood pDC levels in patients in complete remission. These findings show preferential recruitment of pDC into tumors where they express a partially mature phenotype that may reflect an in situ activation. Importantly, compared with pDC found in ascites or blood, tumor-associated pDC (TApDC) produced less IFN-?, TNF-?, IL-6, macrophage inflammatory protein-1?, and RANTES in response to toll-like receptor stimulation, and alterations in pDC functions were mainly mediated through tumor-derived TNF-? and TGF-?. Unlike ascites-derived pDC, TApDC induced IL-10 production from allogeneic naive CD4+ T lymphocytes, suggesting the existence of a paracrine immunosuppressive loop. Taken together, our findings indicate that both local and systemic dysfunction of pDC play a critical role in the progression of ovarian cancer via induction of immune tolerance. Cancer Res; 71(16); 5423–34. ©2011 AACR.
    cancerres.aacrjournals.org   ...Read On

    If up until recently anyone would have told you that voluntarily you would sit down with a group of strangers to discuss your innermost feelings, the odds are good that you would have laughed. Unfortunately, being diagnosed with ovarian cancer most likely stood your world on its head and you may now find yourself a www.drgeorgekarlis.net


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    Women with ovarian cancer could be helped by a new test that identifies the specific type of tumour they have, a conference will hear this week. (2011-05-31)
    www.brightsurf.com   ...Read On


    		   
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