A recent U.S. study found that smoking increases a common arrhythmia – atrial fibrillation risk, this is the first link found in smoking and atrial fibrillation.
The study involved 15,000 adults aged 45 to 64. The researchers conducted a survey on the average being 13 years of follow-up survey, during which the survey was a total of 876 people suffering from atrial fibrillation.
The researchers compared the risk of smokers and non smokers chances of atrial fibrillation. The results showed that, compared with never smokers, had quit smoking but then the person suffering from atrial fibrillation risk 1.32 times higher, current smokers will have more than 2 times.
Atrial fibrillation, is the loss of regular cardiac contractile activity, rather than replace them with the coordination of rapid vibration, resulting in atrial contraction can not be properly effective. It can cause serious complications such as heart failure and arterial embolism, a serious threat to health.
According to statistics, the United States each year with newly diagnosed cases of atrial fibrillation of 16 million. Previous studies have found that obesity, hypertension and diabetes are risk factors that lead to atrial fibrillation. This latest study confirmed that atrial fibrillation is also associated with smoking.
Research published in the new issue of "Heart Rhythm" magazine.
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Received 22 December 2010; accepted 11 March 2011. published online 17 March 2011.
Smoking and incidence of atrial fibrillation: Results from the Atherosclerosis Risk in Communities (ARIC) Study
Alanna M. Chamberlain, PhD, MPH, Sunil K. Agarwal, MD, MPH, Aaron R. Folsom, MD, MPH, Sue Duval, PhD, Elsayed Z. Soliman, MD, MSc, MS, Marietta Ambrose, MD, Lynn E. Eberly, PhD, Alvaro Alonso, MD, PhD
Background
Cigarette smoking increases the risk of coronary heart disease, but whether smoking increases atrial fibrillation (AF) is uncertain.
Objective
The purpose of this study was to determine the association of cigarette smoking with incident AF in a population-based cohort of blacks and whites.
Methods
We determined the risk of incident AF through December 2002 in relation to baseline (1987–1989) smoking status and cigarette-years of smoking in over 15,000 participants of the prospective Atherosclerosis Risk in Communities (ARIC) study.
Results
Over a mean follow-up of 13.1 years, 876 incident AF events were identified. Compared to never smokers, the multivariable-adjusted hazard ratios (HRs) for AF were 1.32 (95% confidence interval [CI] 1.10–1.57) in former smokers, 2.05 (95% CI 1.71–2.47) in current smokers, and 1.58 (95% CI 1.35–1.85) in ever smokers. In the highest tertile of accumulated smoking amount (>675 cigarette-years), the incidence of AF was 2.10 times greater (95% CI 1.74–2.53) than in those who never smoked. Associations were similar by gender, race, type of event (AF and atrial flutter), and when only AF events identified by study exam ECGs were included. Finally, individuals who quit smoking exhibited a trend indicating a slightly lower risk of developing AF (HR 0.88, 95% CI 0.65–1.17) compared to those who continued to smoke.
Conclusion
Smoking was associated with the incidence of AF, with more than a two-fold increased risk of AF attributed to current smoking. In addition, a trend toward a lower incidence of AF appeared among smokers who quit compared to continued smokers.
Incoming search terms for the article:atrial fibrillation and smoking potCigarette Smoking Results In An Increased Risk Of Developing Atrial Fibrillationnew atherosclerosis treatment www.2n2u.com
Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain (IL-2Rγ). The results, which appeared in a recent Proceedings of the National Academy of Sciences, suggest news targets for lymphoma and other types of cancer. www.physorg.com
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