People at risk for a certain form of colon and other types of cancer may soon have a better chance at surviving or even avoiding the diseases, thanks to a new study done by the Intermountain Clinical Genetics Institute at LDS Hospital. www.physorg.com
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The invasive and costly procedure of inserting an inferior vena cava filter (IVCF) does not benefit cancer patients who are being treated with the anticoagulation medication fondaparinux (Arixtra®) for blood clots. These results were recently presented at the 14th World Conference on Lung Cancer.
Blood clots are the second most common cause of death among cancer news.cancerconnect.com
John Lewis, Ann Chambers and colleagues from Lawson Health Research Institute’s in the "Laboratory Investigation" magazine published its findings: a protein called maspin can inhibit such as breast cancer, ovarian cancer, head and neck cancer and other cancer cells to form , growth and proliferation, but only in its nucleus.
In order to assess maspin protein in tumor growth and development, the researchers selected two cancer tests: the highly aggressive head and neck cancer and may spread to the lymph nodes and lungs of breast cancer. The team will maspin protein into a cell nucleus, and the other was outside of denial in the nucleus, then were injected into chicken embryos and mouse cancer models.
The results show that when maspin protein was injected into Nuclear of the cancer cells , its basic ability to significantly reduce the spread, the incidence of metabolic rate from 75% to 40%; and maspin protein in the nucleus when the cancer cells spread more easily. These findings suggest that, maspin protein in the cell’s position is clearly affected the behavior of cancer cells, which ultimately determines the spread of cancer and treatment. However, maspin protein location in cells may lead to different positive and negative results, this information will now be used to predict the progress of cancer patients a little bit difficult.
The researchers said that the metabolism of cancer cause of death accounted for 90%, while the nucleus of the maspin protein significantly reduced the extent of cancer and size of distant metastases. This study may help doctors better understand the spread of cancer, to provide new targets for drug development.
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Laboratory Investigation 91, 1181-1187 (August 2011)
doi:10.1038/labinvest.2011.66
Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis
Brigitte Goulet, Wendy Kennette, Amber Ablack, Carl O Postenka, M Nicole Hague, Joe S Mymryk, Alan B Tuck, Vincent Giguère, Ann F Chambers and John D Lewis
Abstract
Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in human cancer is controversial. Maspin expression has been associated with a poor prognosis in some studies, whereas in others, with favorable outcome. The clinical data suggest, however, that nuclear-localized maspin is associated with improved survival. We hypothesized that the tumor suppressor activity of maspin may require nuclear localization, and that the discordance between clinical and experimental reports is a consequence of the variable subcellular distribution of maspin. Furthermore, we surmized that nuclear maspin could function as a tumor suppressor through the regulation of genes involved in tumor growth and invasion. Maspin or maspin fused to a nuclear export signal were expressed in metastatic human breast and epidermoid carcinoma cell lines. We found that pan-cellular localized maspin inhibited in vivo tumor growth and metastasis when assessed in xenograft chicken embryo and murine mammary fat pad injection models. However, when maspin was excluded from the nucleus via a nuclear exclusion signal, it no longer functioned as a metastasis suppressor. Using chromatin immunoprecipitation, we show that nuclear maspin was enriched at the promoter of colony-stimulating factor-1 (CSF-1) and associated with diminished levels of CSF-1 mRNA. Our findings demonstrate that the nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo, and suggest that its mechanism of action involves, in part, direct association of maspin with target genes.
Incoming search terms for the article:Nuclear localization of maspin is essential for its inhibition of tumor gro www.2n2u.com
HealthDay - FRIDAY, Aug. 12 (HealthDay News) -- Listening to music or having
sessions with trained music therapists can help ease cancer patients'
anxiety, researchers say. us.rd.yahoo.com
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