A new global analysis has found an increase in the number of cases and deaths from breast and cervical cancer, especially in the developing countries where more young women are dying early.
Breast cancer cases more than doubled around the world in just three decades, from 641,000 cases in 1980 to 1.6 million cases in 2010, a pace that far exceeds global population growth, according to the study by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington.
In a study that evaluated two generations of women with BRCA1 or BRCA2 mutations, breast and ovarian cancers tended to be diagnosed at a younger age in the later generation. These results were published in Cancer.
Inherited mutations in two genes—BRCA1 and BRCA2—have been found to greatly increase the lifetime risk of developing breast and ovarian news.cancerconnect.com
Researchers from the University of Illinois at Chicago wondered about this. After all, the components of what experts call "psychosocial stress" - including fear, anxiety and isolation - could take a toll on the autonomic nervous system, which helps regulate heart rate, respiration and other important bodily functions. www.topix.com
Researchers have found that a protein linked to cell division and migration and tied to increased cell proliferation in ovarian tumors is also present at high levels in breast cancer specimens and cell lines. The protein, dubbed “UNC-45A,” was also determined to be more active in breast cancer cells than in normal breast cells.
University of Texas Medical Branch at Galveston scientists describe these findings and others in a paper now online in the Journal of Molecular Biology.
“As a result of earlier work, we hypothesized that UNC-45A should be critical in several steps related to cancer cell metastasis,” said UTMB professor Henry Epstein. “This investigation confirmed that hypothesis, and also showed us significant aspects of UNC-45A’s behavior that were previously unknown.” www.health.am
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