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PTH battles TGF-? in bone image

PTH battles TGF-? in bone


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•March 17, 2010
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PTH battles TGF-? in bone art
 


PTH battles TGF-β in bone

Nature Cell Biology 12, 205 (2010). doi:10.1038/ncb0310-205

Authors: Azeddine Atfi & Roland Baron

Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-β). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-β type II receptor (TβRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-β and PTH signalling in vivo.


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